New polymeric photosensitizers

New polymeric photosensitizers*

Novel polymeric photosensitizers for singlet oxygen production in water are described. The polymers contain rose bengal (4,5,6,7-tetrachloro-2',4',5',7'–tetraiodo-fluorescein) chromophores covalently attached to the polymer chain. The quantum yields of singlet oxygen formation and photooxidation of phenol in water have been determined. The methods of separation of photosensitizer from the react...

Polymeric micelles to deliver photosensitizers for photodynamic therapy.

Polymeric micelles are emerging as attractive drug delivery systems. Hydrophobic drugs including photosensitizers for photodynamic therapy can be covalently bound or physically entrapped in the core of the micelles and thus be systemically delivered to, for example, tumors using passive or active targeting strategies. Polymers used for photosensitizer encapsulation include pluronics, poly(ethyl...

Methacrylamide-oligolactates as building blocks for targeted biodegradable polymeric micelles to deliver photosensitizers.

New drug delivery systems based on polymeric silk fibroin

Nowadays, design and synthesis of efficient drug delivery systems are of vital importance in order to optimize the efficacy of therapeutics and reducing side effects. So far, many drug delivery systems have been designed, among them, natural polymer-based systems have attracted the most attention. Silk fibroin (SF) as a natural polymer have several unique properties including excellent biocompa...

Platelets, photosensitizers, and PDT.

Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in anti-angiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigatio...